I hope the tE2 does what tE2 has been doing for Canadians and EU PCa patients to reduce testosterone for many years. In this country, thank big pharma, urologists, the AMA and hospital lawyers for settling the malpractice lawsuit against Abbot Labs by removing OTC tE2 from pharmacy shelves and making ADT drugs the only game in town with prescription access only from urology practices.
I'm sure you know that you can acquire tE2 gel and patches OTC in Mexico, Thailand and the EU. It is inexpensive and why countries with national healthcare have been using tE2 for ADT treatment. It is too cheap for pharma to make extraordinary profits protected by a patent.
When my BF could not tolerate injected ADT, he tried the repurposed drugs and supplements for a year and a half. He had the same Gleason and other features plus perineural invasion. Was classified as having a highly aggressive PC with numerous Mets to bone and lymph nodes. After scans showed some spread, he decided to try Orgovyx and Nubeqa. The only symptom is mild hot flashes which have been very tolerable. No fatigue. No pain. He says he feels fantastic! PSA dropped from 276 to .4 in 6 months and is still dropping. The beauty of Orgovyx is that it is a daily pill and you can stop if the side effects are too much. 3 months after starting ADT drugs his scan showed an overall decrease in lesions of 70-90%. I do think the repurposed drugs are acting synergistically with the ADT. Alkaline phosphatase 61 and LDH is 119, and CRP is .5. All other bloodwork is normal or very close to normal. We are looking forward to the next scan in October. Best wishes and thanks for sharing.
Keith, here is my attempt at trying to replicate my original post. How can it be that joy and suffering are 2 sides to the same coin of life. They are intrinsically connected to one another; to understand the fullness of one, you need to experience the other. As an N of 1, you have been able to courageously experience both. Beyond that you remain a beacon of compassion, kindness and hope to those in the prostate cancer community. I will continue to hold you up in prayer my friend for healing in all ways that God can physically, emotionally and spiritually. Stay Blessed 😇🙏
Thank you so much. You are a trooper taking on triplet therapy, and I wish you all the best. And there actually is some really good news coming in the next installment.
Keith, I left a message here but don’t see it. I don’t know if there is a time lapse to when they appear. If I don’t see my original one, I hope my brain can regenerate it.
The hardest part of my treatment is that the doctors don’t actually know what to do, they simply guess. And so then I’m left with the dilemma of making an uninformed decision other than what I can find out by research on my own.
Yes it's a very tricky disease and that's why guidelines exists, even though they are definitely not perfect. I think the best docs consider guidelines and think out of the box. I'm sorry you are dealing with this terrible disease and I wish you the best! I hope you find a doc like that, and one you resonate with and trust.
Thank you for the informative article. Have the liver alk phos levels been checked following bone mets? Usually that would indicate a certain level of activity in the osteoclasts/ blasts. Also, have you considered isoflavone+ Dim? The findings (although not yet clinical) suggest the combination interrupts osteopontin, RUNX2 and RANKLE signalling, which is driven by the mets
Hi Joe. My ALP in mid April was low normal, six weeks before the PET. We'll check it again next set of labs. Thanks for the idea about isoflavone + DIM.
My next PSA test is in October - I've been undetectable since my RARP in September 2024. But I'm always a little anxious before every test. With many friends dealing with ADT side effects it's hard not to think "when will it be my turn?" I bought the book and look forward to reading it (I've also shared the link to the Gay Men Loving Gay Books group on FB that has over 17K members). Good luck!
Hi Steve. Thank you so much! Trust that your PSA will remain undetectable. It reminds your body you do trust it and keeps your sympathetic tone down. Take brother!
Sorry you had this progression. Have you heard of saw palmetto? It also lowers testosterone but in a natural way. I have seen it work in my blood test because my breast cancer is AR sensitive. Not sure if it’s enough for your case, but thought I would mention. Thanks for sharing your story. Sending healing energy.
BTW, not sure if you've seen this ASPI video, but it has a great piece with Dr. Paul Schellhammer discussing his use of estradiol patches in lieu of ADT:
“…I might have developed a sensitivity to the ivermectin, as the day after taking it caused severe fatigue and dark thoughts.”
Your approach to taking IVM does not appear to be ‘serious’. Seek a physician that has some experience using IVM for Cancer. Parasites are common; their initial ‘die off’ can cause temporary side effects.
Hi Keith,
I hope the tE2 does what tE2 has been doing for Canadians and EU PCa patients to reduce testosterone for many years. In this country, thank big pharma, urologists, the AMA and hospital lawyers for settling the malpractice lawsuit against Abbot Labs by removing OTC tE2 from pharmacy shelves and making ADT drugs the only game in town with prescription access only from urology practices.
I'm sure you know that you can acquire tE2 gel and patches OTC in Mexico, Thailand and the EU. It is inexpensive and why countries with national healthcare have been using tE2 for ADT treatment. It is too cheap for pharma to make extraordinary profits protected by a patent.
Hi Jeff. Thanks for that info. I didn't know tE2 is available OTC in those countries.
When my BF could not tolerate injected ADT, he tried the repurposed drugs and supplements for a year and a half. He had the same Gleason and other features plus perineural invasion. Was classified as having a highly aggressive PC with numerous Mets to bone and lymph nodes. After scans showed some spread, he decided to try Orgovyx and Nubeqa. The only symptom is mild hot flashes which have been very tolerable. No fatigue. No pain. He says he feels fantastic! PSA dropped from 276 to .4 in 6 months and is still dropping. The beauty of Orgovyx is that it is a daily pill and you can stop if the side effects are too much. 3 months after starting ADT drugs his scan showed an overall decrease in lesions of 70-90%. I do think the repurposed drugs are acting synergistically with the ADT. Alkaline phosphatase 61 and LDH is 119, and CRP is .5. All other bloodwork is normal or very close to normal. We are looking forward to the next scan in October. Best wishes and thanks for sharing.
Hi Claire. Thanks for the information. I'll keep that in mind. Sorry y'all are going through this and I wish you both the very best.
Keith, here is my attempt at trying to replicate my original post. How can it be that joy and suffering are 2 sides to the same coin of life. They are intrinsically connected to one another; to understand the fullness of one, you need to experience the other. As an N of 1, you have been able to courageously experience both. Beyond that you remain a beacon of compassion, kindness and hope to those in the prostate cancer community. I will continue to hold you up in prayer my friend for healing in all ways that God can physically, emotionally and spiritually. Stay Blessed 😇🙏
Thanks John. Your kindness and support mean so much to me.
It goes both ways.
Keith
Thanks for the informative - and well-written- post.
I'm just over halfway through the chemotherapy part of Triplet therapy. Planning for RT in about 2 months.
For me, it's all fine so far.
I found your thoughts on progression / castrate-resistance to be very enlightening. I had never thought about the evolutionary fight-back.
I look forward to good news in the next instalment. Thanks again.
Thank you so much. You are a trooper taking on triplet therapy, and I wish you all the best. And there actually is some really good news coming in the next installment.
Keith, I left a message here but don’t see it. I don’t know if there is a time lapse to when they appear. If I don’t see my original one, I hope my brain can regenerate it.
I just got my answer. I’ll have to try and bring back all those thoughts to my frontal cortex.
The hardest part of my treatment is that the doctors don’t actually know what to do, they simply guess. And so then I’m left with the dilemma of making an uninformed decision other than what I can find out by research on my own.
Yes it's a very tricky disease and that's why guidelines exists, even though they are definitely not perfect. I think the best docs consider guidelines and think out of the box. I'm sorry you are dealing with this terrible disease and I wish you the best! I hope you find a doc like that, and one you resonate with and trust.
Hi Keith,
Thank you for the informative article. Have the liver alk phos levels been checked following bone mets? Usually that would indicate a certain level of activity in the osteoclasts/ blasts. Also, have you considered isoflavone+ Dim? The findings (although not yet clinical) suggest the combination interrupts osteopontin, RUNX2 and RANKLE signalling, which is driven by the mets
Hi Joe. My ALP in mid April was low normal, six weeks before the PET. We'll check it again next set of labs. Thanks for the idea about isoflavone + DIM.
My next PSA test is in October - I've been undetectable since my RARP in September 2024. But I'm always a little anxious before every test. With many friends dealing with ADT side effects it's hard not to think "when will it be my turn?" I bought the book and look forward to reading it (I've also shared the link to the Gay Men Loving Gay Books group on FB that has over 17K members). Good luck!
Hi Steve. Thank you so much! Trust that your PSA will remain undetectable. It reminds your body you do trust it and keeps your sympathetic tone down. Take brother!
Sorry you had this progression. Have you heard of saw palmetto? It also lowers testosterone but in a natural way. I have seen it work in my blood test because my breast cancer is AR sensitive. Not sure if it’s enough for your case, but thought I would mention. Thanks for sharing your story. Sending healing energy.
Thanks for your comment. I haven't seen any literature about using SP in PCa, but I'll let you know if I do.
Hi Keith, I read this with interest. We all follow different paths. I just wondered if you considered chemotherapy before using alternative therapies?
Yes we do. I have had a long run without ADT and really was happy about that. The idea of chemo isn't something I resonate with.
I can tell you chemo sucks. But in my case it has helped control the disease. Good luck to you on your road.
Thank you!
Perhaps an eBook on off-label use of estradiol patches would be great. In any case, all the best, Dr. Holden!
Hi Pete. That's actually a great idea. Thanks!
Sure, Dr. Holden, hope you write such an eBook!
BTW, not sure if you've seen this ASPI video, but it has a great piece with Dr. Paul Schellhammer discussing his use of estradiol patches in lieu of ADT:
https://aspatients.org/meeting/cancer-proof-doctors-with-prostate-cancer-lessons-from-the-patient-side-of-the-exam-table/
Starting at 41:35 – Dr. Paul Schellhammer: 25 years with prostate cancer and living with advanced disease
Best wishes to you, Dr Holden. Sending positive vibes your way!!
Hi Dr. Flora. Thank you and I'm sending good vibes back to you.
I'm very familiar with him. Thanks! https://www.urologytimes.com/view/estradiol-and-adt-lessons-from-lived-experience
“…I might have developed a sensitivity to the ivermectin, as the day after taking it caused severe fatigue and dark thoughts.”
Your approach to taking IVM does not appear to be ‘serious’. Seek a physician that has some experience using IVM for Cancer. Parasites are common; their initial ‘die off’ can cause temporary side effects.
Good Luck 🍀