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ClaireD's avatar

When my BF could not tolerate injected ADT, he tried the repurposed drugs and supplements for a year and a half. He had the same Gleason and other features plus perineural invasion. Was classified as having a highly aggressive PC with numerous Mets to bone and lymph nodes. After scans showed some spread, he decided to try Orgovyx and Nubeqa. The only symptom is mild hot flashes which have been very tolerable. No fatigue. No pain. He says he feels fantastic! PSA dropped from 276 to .4 in 6 months and is still dropping. The beauty of Orgovyx is that it is a daily pill and you can stop if the side effects are too much. 3 months after starting ADT drugs his scan showed an overall decrease in lesions of 70-90%. I do think the repurposed drugs are acting synergistically with the ADT. Alkaline phosphatase 61 and LDH is 119, and CRP is .5. All other bloodwork is normal or very close to normal. We are looking forward to the next scan in October. Best wishes and thanks for sharing.

J. P. Dwyer's avatar

Hi Keith,

I hope the tE2 does what tE2 has been doing for Canadians and EU PCa patients to reduce testosterone for many years. In this country, thank big pharma, urologists, the AMA and hospital lawyers for settling the malpractice lawsuit against Abbot Labs by removing OTC tE2 from pharmacy shelves and making ADT drugs the only game in town with prescription access only from urology practices.

I'm sure you know that you can acquire tE2 gel and patches OTC in Mexico, Thailand and the EU. It is inexpensive and why countries with national healthcare have been using tE2 for ADT treatment. It is too cheap for pharma to make extraordinary profits protected by a patent.

Pete's avatar

Perhaps an eBook on off-label use of estradiol patches would be great. In any case, all the best, Dr. Holden!

Daniel Flora, MD's avatar

Best wishes to you, Dr Holden. Sending positive vibes your way!!